Which isoform of Levomethadyl acetate is the most potent?

The European Medicines Evaluation Agency's (EMEA) scientific committee, the Committee for Proprietary Medicinal Products (CPMP) has been evaluating new safety information as it emerges. The patients experiencing symptoms suggesting the occurrence of a severe arrhythmia (torsade de pointes) such as palpitations, dizziness, syncope or convulsion should seek urgent medical advice. Levacetylmethadol should be discontinued, and the patient should be evaluated for QT prolongation and arrhythmias.

LAAM appears more effective than methadone at reducing heroin use. More LAAM patients than methadone ceased their allocated medication during the studies, but many transferred to methadone and so the significance of this is unclear. It was formerly available under the brand name Orlaam, but this product was removed from the market years ago due to concerns about its effect on the heart. Today, LAAM is only administered through authorized treatment programs that are committed to closely monitoring everyone who is given the drug. LAAM, or levomethadyl acetate, is the levo isomer of acetylmethadol, or α-methadyl acetate. The dextro isomer, d-alphacetylmethadol (d-α-acetylmethadol), is more potent but shorter acting. An alternative to methadone is a medication known as LAAM which is also primarily used as a replacement therapy for opiate drugs. LAAM is sometimes preferred to methadone because it requires less frequent dosing, allowing for fewer clinic visits. Orlaam is indicated for the substitution maintenance treatment of opiate addiction in adults previously treated with methadone, as part of a comprehensive treatment plan including medical, social and psychological care. The European Medicines Evaluation Agency's (EMEA) scientific committee, the Committee for Proprietary Medicinal Products (CPMP) has been evaluating new safety information as it emerges. The patients experiencing symptoms suggesting the occurrence of a severe arrhythmia (torsade de pointes) such as palpitations, dizziness, syncope or convulsion should seek urgent medical advice. Levacetylmethadol should be discontinued, and the patient should be evaluated for QT prolongation and arrhythmias.